Nature Communications (Aug 2021)
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology
- Gail P. Risbridger,
- Ashlee K. Clark,
- Laura H. Porter,
- Roxanne Toivanen,
- Andrew Bakshi,
- Natalie L. Lister,
- David Pook,
- Carmel J. Pezaro,
- Shahneen Sandhu,
- Shivakumar Keerthikumar,
- Rosalia Quezada Urban,
- Melissa Papargiris,
- Jenna Kraska,
- Heather B. Madsen,
- Hong Wang,
- Michelle G. Richards,
- Birunthi Niranjan,
- Samantha O’Dea,
- Linda Teng,
- William Wheelahan,
- Zhuoer Li,
- Nicholas Choo,
- John F. Ouyang,
- Heather Thorne,
- Lisa Devereux,
- Rodney J. Hicks,
- Shomik Sengupta,
- Laurence Harewood,
- Mahesh Iddawala,
- Arun A. Azad,
- Jeremy Goad,
- Jeremy Grummet,
- John Kourambas,
- Edmond M. Kwan,
- Daniel Moon,
- Declan G. Murphy,
- John Pedersen,
- David Clouston,
- Sam Norden,
- Andrew Ryan,
- Luc Furic,
- David L. Goode,
- Mark Frydenberg,
- Mitchell G. Lawrence,
- Renea A. Taylor
Affiliations
- Gail P. Risbridger
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Ashlee K. Clark
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Laura H. Porter
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Roxanne Toivanen
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Andrew Bakshi
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Natalie L. Lister
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- David Pook
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Carmel J. Pezaro
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Shahneen Sandhu
- Sir Peter MacCallum Department of Oncology, The University of Melbourne
- Shivakumar Keerthikumar
- Cancer Research Division, Peter MacCallum Cancer Centre
- Rosalia Quezada Urban
- Cancer Research Division, Peter MacCallum Cancer Centre
- Melissa Papargiris
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Jenna Kraska
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Heather B. Madsen
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Hong Wang
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Michelle G. Richards
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Birunthi Niranjan
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Samantha O’Dea
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Linda Teng
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- William Wheelahan
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Zhuoer Li
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Physiology, Monash University
- Nicholas Choo
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- John F. Ouyang
- Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School
- Heather Thorne
- Cancer Research Division, Peter MacCallum Cancer Centre
- Lisa Devereux
- Cancer Research Division, Peter MacCallum Cancer Centre
- Rodney J. Hicks
- Center for Molecular Imaging, Peter MacCallum Cancer Center
- Shomik Sengupta
- Eastern Health and Monash University Eastern Health Clinical School
- Laurence Harewood
- Epworth Healthcare
- Mahesh Iddawala
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Arun A. Azad
- Sir Peter MacCallum Department of Oncology, The University of Melbourne
- Jeremy Goad
- Sir Peter MacCallum Department of Oncology, The University of Melbourne
- Jeremy Grummet
- Epworth Healthcare
- John Kourambas
- Department of Medicine, Monash Health, Casey Hospital
- Edmond M. Kwan
- Department of Medicine, School of Clinical Sciences, Monash University
- Daniel Moon
- Epworth Healthcare
- Declan G. Murphy
- Sir Peter MacCallum Department of Oncology, The University of Melbourne
- John Pedersen
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- David Clouston
- TissuPath
- Sam Norden
- TissuPath
- Andrew Ryan
- TissuPath
- Luc Furic
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- David L. Goode
- Cancer Research Division, Peter MacCallum Cancer Centre
- Mark Frydenberg
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Mitchell G. Lawrence
- Prostate Cancer Research Group, Monash Biomedicine Discovery Institute, Cancer Program, Department of Anatomy and Developmental Biology, Monash University
- Renea A. Taylor
- Cancer Research Division, Peter MacCallum Cancer Centre
- DOI
- https://doi.org/10.1038/s41467-021-25175-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
The prognosis of castration-resistant prostate cancers remains dismal, but accurate preclinical models can lead to effective therapies. Here the Melbourne Urological Research Alliance establish prostate cancer patient-derived xenografts, use the tumors for organoids and single-cell RNA-seq, and show the efficacy of PARP inhibitor combination treatments.
