MEXICOR EFFECTIVENESS IN PATIENTS WITH BRADYARRHYTHMIAS

Abstract

The study aimed at mexicor effectiveness assessment in patients with bradyarrhythmias. Among 19 individuals with bradyarrhythmias, 9 patients (main group) received standard therapy plus intravenous mexicor (300 mg/d), and 10 participants were administered standard therapy only (control group). Mexicor effects on subjective clinical status and physical stress tolerance, sinus node automatism (transoesophageal electrophysiological examination, 24-hour ECG monitoring) and central hemodynamics (echocardiography) were assessed in comparison with respective parameters in the control group. The patients receiving mexicor demonstrated improved functional activity of sinus node, reduced number of supraventricular and ventricular extrasystoles, and improved left ventricular pump function. Including mexicor in the complex therapy of bradyarrhythmia patients also improved their clinical status and physical stress tolerance: the number of subjective complaints decreased, and the distance in the 6-minute walk test increased. Mexicor as a part of complex bradyarrhythmia therapy improved the effectiveness of standard treatment, assessed by various parameters.

Keywords

• bradyarrhythmias
• mexicor
• effectiveness