A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection

Wenjuan Wang; Zihou Deng; Hongyu Wu; Qun Zhao; Tiantian Li; Wencheng Zhu; Xiongjun Wang; Longhai Tang; Chengshu Wang; Shu-Zhong Cui; Hui Xiao; Jiangye Chen

doi:10.1038/s41467-019-08950-3

Nature Communications (Mar 2019)

A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection

Wenjuan Wang,
Zihou Deng,
Hongyu Wu,
Qun Zhao,
Tiantian Li,
Wencheng Zhu,
Xiongjun Wang,
Longhai Tang,
Chengshu Wang,
Shu-Zhong Cui,
Hui Xiao,
Jiangye Chen

Affiliations

Wenjuan Wang: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Zihou Deng: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Hongyu Wu: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Qun Zhao: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Tiantian Li: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Wencheng Zhu: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Xiongjun Wang: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Longhai Tang: Suzhou Blood Center
Chengshu Wang: CAS Key Laboratory of Insect Developmental and Evolutionary Biology, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences
Shu-Zhong Cui: State Key Laboratory of Respiratory Diseases, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Medical University
Hui Xiao: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Jiangye Chen: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-019-08950-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The interplay between fungal pathogens and the innate immune system remains incompletely understood. Here, Wang et al. show that a small protein secreted by Candida albicans induces a TLR2- and TLR4-mediated inflammatory response in a mouse infection model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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