Communications Chemistry (Jun 2024)

NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing

  • Irfan Ullah,
  • Shahin Shah Khan,
  • Waqar Ahmad,
  • Luo Liu,
  • Ahmed Rady,
  • Badr Aldahmash,
  • Yingjie Yu,
  • Jian Wang,
  • Yushu Wang

DOI
https://doi.org/10.1038/s42004-024-01215-1
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Abstract Nanoparticle-based therapies are emerging as a pivotal frontier in biomedical research, showing their potential in combating infections and facilitating wound recovery. Herein, selenium-tellurium dopped copper oxide nanoparticles (SeTe-CuO NPs) with dual photodynamic and photothermal properties were synthesized, presenting an efficient strategy for combating bacterial infections. In vitro evaluations revealed robust antibacterial activity of SeTe-CuO NPs, achieving up to 99% eradication of bacteria and significant biofilm inhibition upon near-infrared (NIR) irradiation. Moreover, in vivo studies demonstrated accelerated wound closure upon treatment with NIR-activated SeTe-CuO NPs, demonstrating their efficacy in promoting wound healing. Furthermore, SeTe-CuO NPs exhibited rapid bacterial clearance within wounds, offering a promising solution for wound care. Overall, this versatile platform holds great promise for combating multidrug-resistant bacteria and advancing therapeutic interventions in wound management.