Derivation of induced pluripotent stem cells (SDUKIi003-A) from a 20-year-old male patient diagnosed with Asperger syndrome

Morad Kamand; Mirolyuba Ilieva; Sheena Louise Forsberg; Mads Thomassen; Morten Meyer; Åsa Fex Svenningsen; Tanja Maria Michel

Stem Cell Research (Oct 2020)

Derivation of induced pluripotent stem cells (SDUKIi003-A) from a 20-year-old male patient diagnosed with Asperger syndrome

Morad Kamand,
Mirolyuba Ilieva,
Sheena Louise Forsberg,
Mads Thomassen,
Morten Meyer,
Åsa Fex Svenningsen,
Tanja Maria Michel

Affiliations

Morad Kamand: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Institute of Molecular Medicine, Department of Neurobiology Research, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark; Corresponding authors at: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark (M. Kamand); Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark (T. Maria Michel).
Mirolyuba Ilieva: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark
Sheena Louise Forsberg: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark
Mads Thomassen: Department of Clinical Research, Department of Human Genetics, Odense University Hospital, Denmark
Morten Meyer: Institute of Molecular Medicine, Department of Neurobiology Research, University of Southern Denmark, Odense, Denmark; Brain Research - Inter Disciplinary Guided Excellence (BRIDGE), Odense, Denmark; Department of Neurology, Odense University Hospital, Denmark
Åsa Fex Svenningsen: Institute of Molecular Medicine, Department of Neurobiology Research, University of Southern Denmark, Odense, Denmark; Brain Research - Inter Disciplinary Guided Excellence (BRIDGE), Odense, Denmark
Tanja Maria Michel: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Brain Research - Inter Disciplinary Guided Excellence (BRIDGE), Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark; Corresponding authors at: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark (M. Kamand); Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark (T. Maria Michel).

Journal volume & issue: Vol. 48
p. 101974

Abstract

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Autism spectrum disorder is a heterogenous neurodevelopmental disorder. The patients experience challenges in social interaction and communication skills as well as restricted and/or repetitive behaviors. To understand the molecular mechanisms underlying developmental brain disorders, patient-derived cellular models represent a useful tool. We have generated a human induced pluripotent stem cell line (SDUKIi003-A) from skin fibroblasts derived from a 20-year old male patient diagnosed with Asperger syndrome (“FYNEN-cohort” of Southern Denmark). The reprogramming of the fibroblasts was accomplished using integration-free episomal plasmids. Characterization validated the expression of pluripotency markers, differentiation into the three germ layers, and absence of chromosomal abnormalities.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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