Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V

Arash Ahmadi; Ida Rosnes; Pernille Blicher; Robin Diekmann; Mark Schüttpelz; Kyrre Glette; Jim Tørresen; Magnar Bjørås; Bjørn Dalhus; Alexander D. Rowe

doi:10.1038/s41467-018-07797-4

Nature Communications (Dec 2018)

Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V

Arash Ahmadi,
Ida Rosnes,
Pernille Blicher,
Robin Diekmann,
Mark Schüttpelz,
Kyrre Glette,
Jim Tørresen,
Magnar Bjørås,
Bjørn Dalhus,
Alexander D. Rowe

Affiliations

Arash Ahmadi: Department of Medical Biochemistry, Institute for Clinical Medicine, University of Oslo
Ida Rosnes: Department of Medical Biochemistry, Institute for Clinical Medicine, University of Oslo
Pernille Blicher: Department of Medical Biochemistry, Institute for Clinical Medicine, University of Oslo
Robin Diekmann: Biomolecular Photonics, Department of Physics, University of Bielefeld
Mark Schüttpelz: Biomolecular Photonics, Department of Physics, University of Bielefeld
Kyrre Glette: Department of Informatics, University of Oslo
Jim Tørresen: Department of Informatics, University of Oslo
Magnar Bjørås: Department of Microbiology, Oslo University Hospital HF, Rikshospitalet and University of Oslo
Bjørn Dalhus: Department of Medical Biochemistry, Institute for Clinical Medicine, University of Oslo
Alexander D. Rowe: Department of Medical Biochemistry, Institute for Clinical Medicine, University of Oslo

DOI: https://doi.org/10.1038/s41467-018-07797-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

Read online

How DNA repair proteins locate their target sites on DNA is still a matter of debate. Here the authors characterize by single-molecule fluorescence imaging the modes of scanning adopted by bacterial endonuclease V as it moves along linear DNA tracks.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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