Diabetes & Metabolism Journal (Aug 2013)

Serum Adiponectin and Type 2 Diabetes: A 6-Year Follow-Up Cohort Study

  • Sun Ha Jee,
  • Chul Woo Ahn,
  • Jong Suk Park,
  • Chang Gyu Park,
  • Hyon-Suk Kim,
  • Sang-Hak Lee,
  • Sungha Park,
  • Myoungsook Lee,
  • Chang Beom Lee,
  • Hye Soon Park,
  • Heejin Kimm,
  • Sung Hee Choi,
  • Jidong Sung,
  • Seungjoon Oh,
  • Hyojee Joung,
  • Sung Rae Kim,
  • Ho-Joong Youn,
  • Sun Mi Kim,
  • Hong Soo Lee,
  • Yejin Mok,
  • Eunmi Choi,
  • Young Duk Yun,
  • Soo-Jin Baek,
  • Jaeseong Jo,
  • Kap Bum Huh

DOI
https://doi.org/10.4093/dmj.2013.37.4.252
Journal volume & issue
Vol. 37, no. 4
pp. 252 – 261

Abstract

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BackgroundStudies on factors which may predict the risk of diabetes are scarce. This prospective cohort study was conducted to determine the association between adiponectin and type 2 diabetes among Korean men and women.MethodsA total of 42,845 participants who visited one of seven health examination centers located in Seoul and Gyeonggi province, Republic of Korea between 2004 and 2008 were included in this study. The incidence rates of diabetes were determined through December 2011. To evaluate the effects of adiponectin on type 2 diabetes, the Cox proportional hazard model was used.ResultsOf the 40,005 participants, 959 developed type 2 diabetes during a 6-year follow-up. After the adjustment for age, body mass index (BMI), and waist circumference, the risks for type 2 diabetes in participants with normoglycemia had a 1.70-fold (95% confidence interval [CI], 1.21 to 2.38) increase in men and a 1.83-fold (95% CI, 1.17 to 2.86) increase in women with the lowest tertile of adiponectin when compared to the highest tertile of adiponectin. For participants with impaired fasting glucose (IFG), the risk for type 2 diabetes had a 1.46-fold (95% CI, 1.17 to 1.83) increase in men and a 2.52-fold (95% CI, 1.57 to 4.06) increase in women with the lowest tertile of adiponectin. Except for female participants with normoglycemia, all the risks remained significant after the adjustment for fasting glucose and other confounding variables. Surprisingly, BMI and waist circumference were not predictors of type 2 diabetes in men or women with IFG after adjustment for fasting glucose and other confounders.ConclusionA strong association between adiponectin and diabetes was observed. The use of adiponectin as a predictor of type 2 diabetes is considered to be useful.

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