Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.

Abstract

Background: : The prevalence of depression with hypothyroidism is high. Objective: : To study the ability of aerobic exercise to improve hypothyroidism associated depression and to explore the underlying mechanisms. Materials and methods: 21 adult male rats, allocated in three groups; Euthyroid, Hypothyroid (oral propyl-thiouracil for 45 days), Exercise-treated hypothyroid group (30 minutes, swimming, 4 weeks). Forced swim test and histopathological brain examination were performed. Serum free T3, T4, TSH, irisin, brain neurochemical, oxidant-antioxidant and apoptotic markers were measured. Results: : Swimming exercise increased serum T3, T4, climbing and swimming times, brain serotonin, BDNF expression, glutathione peroxidase, antiapoptotic Bcl-2 and serum irisin levels and decreased TSH, immobility time, MDA, BAX/Bcl-2 ratio. Climbing time was positively correlated with BDNF, serotonin and T3. Conclusion: : Moderate aerobic exercise alleviated hypothyroidism-associated depression, via increased BDNF expression, which enhances hippocampal neurogenesis, serotonergic system activity and combat neuronal apoptosis.

Keywords

• Hypothyroidism- depression- serotonin-irisin
• BDNF- aerobic exercise