Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design

• Haiying Qin,
• Nirali N Shah,
• Terry J Fry,
• Lila Yang,
• John A Chukinas,
• Samiksha Tarun,
• Marie Pouzolles,
• Christopher D Chien,
• Lisa M Niswander,
• Anthony R Welch,
• Sarah K Tasian,
• Naomi A Taylor

Affiliations

Haiying Qin

National Institutes of Health, Bethesda, Maryland, USA

Nirali N Shah

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA

Terry J Fry

Division of Hematology/Oncology/BMT, Children`s Hospital Colorado, Aurora, Colorado, USA

Lila Yang

National Institutes of Health, Bethesda, Maryland, USA

John A Chukinas

Division of Oncology and Center for Childhood Cancer Research, The Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

Samiksha Tarun

National Institutes of Health, Bethesda, Maryland, USA

Marie Pouzolles

National Institutes of Health, Bethesda, Maryland, USA

Christopher D Chien

National Institutes of Health, Bethesda, Maryland, USA

Lisa M Niswander

Division of Oncology and Center for Childhood Cancer Research, The Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

Anthony R Welch

National Institutes of Health, Bethesda, Maryland, USA

Sarah K Tasian

Division of Oncology and Center for Childhood Cancer Research, The Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

Naomi A Taylor

National Institutes of Health, Bethesda, Maryland, USA