AIDS Research and Therapy (Jun 2011)

T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers

  • Côté Pierre,
  • Thomas Réjean,
  • Routy Jean-Pierre,
  • Boulet Salix,
  • Tsoukas Christos M,
  • Kamya Philomena,
  • Boulassel Mohamed-Rachid,
  • Lessard Bernard,
  • Kaul Rupert,
  • Ostrowski Mario,
  • Kovacs Colin,
  • Tremblay Cecile L,
  • Bernard Nicole F

DOI
https://doi.org/10.1186/1742-6405-8-20
Journal volume & issue
Vol. 8, no. 1
p. 20

Abstract

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Abstract Background Elite controllers (EC) are a rare subset of HIV infected individuals who control viral load below 50 copies/ml of plasma without treatment. Methods Thirty four EC were studied. The slope of CD4 count change was available for 25 of these subjects. We assessed immune activation by measuring the percent of CD38+HLA-DR+CD8+ T cells in the EC group and comparing it with that in 24 treatment-naïve HIV disease progressors and 13 HIV uninfected healthy controls. Results Compared to HIV uninfected subjects, EC had higher percentages of CD38+HLA-DR+CD8+ T cells (p Conclusions Elevated immune activation in ECs is not associated with a faster rate of CD4 decline

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