Nature Communications (Jul 2022)
The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors
- Jasmin Bartl,
- Marco Zanini,
- Flavia Bernardi,
- Antoine Forget,
- Lena Blümel,
- Julie Talbot,
- Daniel Picard,
- Nan Qin,
- Gabriele Cancila,
- Qingsong Gao,
- Soumav Nath,
- Idriss Mahoungou Koumba,
- Marietta Wolter,
- François Kuonen,
- Maike Langini,
- Thomas Beez,
- Christopher Munoz,
- David Pauck,
- Viktoria Marquardt,
- Hua Yu,
- Judith Souphron,
- Mascha Korsch,
- Christina Mölders,
- Daniel Berger,
- Sarah Göbbels,
- Frauke-Dorothee Meyer,
- Björn Scheffler,
- Barak Rotblat,
- Sven Diederichs,
- Vijay Ramaswamy,
- Hiromishi Suzuki,
- Anthony Oro,
- Kai Stühler,
- Anja Stefanski,
- Ute Fischer,
- Gabriel Leprivier,
- Dieter Willbold,
- Gerhard Steger,
- Alexander Buell,
- Marcel Kool,
- Peter Lichter,
- Stefan M. Pfister,
- Paul A. Northcott,
- Michael D. Taylor,
- Arndt Borkhardt,
- Guido Reifenberger,
- Olivier Ayrault,
- Marc Remke
Affiliations
- Jasmin Bartl
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Marco Zanini
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Flavia Bernardi
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Antoine Forget
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Lena Blümel
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Julie Talbot
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Daniel Picard
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Nan Qin
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Gabriele Cancila
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Qingsong Gao
- St Jude Children’s Research Hospital
- Soumav Nath
- Institut für Physikalische Biologie and Biological-Medical Research Center (BMFZ), Heinrich Heine University
- Idriss Mahoungou Koumba
- Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, and DKTK, partner site Essen/Düsseldorf
- Marietta Wolter
- Institute of Neuropathology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, DKTK, partner site Essen/Düsseldorf
- François Kuonen
- Program in Epithelial Biology, Stanford University School of Medicine
- Maike Langini
- Institute for Molecular Medicine, Proteome Research, Medical Faculty, Heinrich Heine University
- Thomas Beez
- Department of Neurosurgery, Medical Faculty, Heinrich Heine University
- Christopher Munoz
- Department of Neurosurgery, Medical Faculty, Heinrich Heine University
- David Pauck
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Viktoria Marquardt
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Hua Yu
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Judith Souphron
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Mascha Korsch
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Christina Mölders
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Daniel Berger
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Sarah Göbbels
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Frauke-Dorothee Meyer
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- Björn Scheffler
- DKFZ Division of Translational Neurooncology at the West German Cancer Center (WTZ), DKTK, partner site University Hospital Essen
- Barak Rotblat
- Department of Life Sciences, Ben-Gurion University of the Negev
- Sven Diederichs
- Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, DKTK, partner site Freiburg
- Vijay Ramaswamy
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Hiromishi Suzuki
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Anthony Oro
- Program in Epithelial Biology, Stanford University School of Medicine
- Kai Stühler
- Molecular Proteomics Laboratory (MPL), BMFZ, Heinrich Heine University
- Anja Stefanski
- Molecular Proteomics Laboratory (MPL), BMFZ, Heinrich Heine University
- Ute Fischer
- Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, and DKTK, partner site Essen/Düsseldorf
- Gabriel Leprivier
- Institute of Neuropathology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, DKTK, partner site Essen/Düsseldorf
- Dieter Willbold
- Institut für Physikalische Biologie and Biological-Medical Research Center (BMFZ), Heinrich Heine University
- Gerhard Steger
- Institut für Physikalische Biologie and Biological-Medical Research Center (BMFZ), Heinrich Heine University
- Alexander Buell
- Department of Biotechnology and Biomedicine, Technical University of Denmark
- Marcel Kool
- Hopp Children´s Cancer Center (KiTZ)
- Peter Lichter
- Division of Molecular Genetics, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT)
- Stefan M. Pfister
- Hopp Children´s Cancer Center (KiTZ)
- Paul A. Northcott
- St Jude Children’s Research Hospital
- Michael D. Taylor
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Arndt Borkhardt
- Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, and DKTK, partner site Essen/Düsseldorf
- Guido Reifenberger
- Institute of Neuropathology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, DKTK, partner site Essen/Düsseldorf
- Olivier Ayrault
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Marc Remke
- Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf
- DOI
- https://doi.org/10.1038/s41467-022-31574-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Long non-coding RNAs (lncRNAs) can contribute to cancers that are driven by Sonic hedgehog (SHH) signaling. Here the authors report that lncRNA HHIP-AS1 stabilises the mRNA of dynein complex 1, thereby, promoting the pro-mitotic effects of SHH-driven tumors.
