Nature Communications (Mar 2019)
Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
- Ye Chen,
- Liang Xu,
- Anand Mayakonda,
- Mo-Li Huang,
- Deepika Kanojia,
- Tuan Zea Tan,
- Pushkar Dakle,
- Ruby Yu-Tong Lin,
- Xin-Yu Ke,
- Jonathan W. Said,
- Jianxiang Chen,
- Sigal Gery,
- Ling-Wen Ding,
- Yan-Yi Jiang,
- Angela Pang,
- Mark Edward Puhaindran,
- Boon Cher Goh,
- H. Phillip Koeffler
Affiliations
- Ye Chen
- Cancer Science Institute of Singapore, National University of Singapore
- Liang Xu
- Cancer Science Institute of Singapore, National University of Singapore
- Anand Mayakonda
- Cancer Science Institute of Singapore, National University of Singapore
- Mo-Li Huang
- Cancer Science Institute of Singapore, National University of Singapore
- Deepika Kanojia
- Cancer Science Institute of Singapore, National University of Singapore
- Tuan Zea Tan
- Cancer Science Institute of Singapore, National University of Singapore
- Pushkar Dakle
- Cancer Science Institute of Singapore, National University of Singapore
- Ruby Yu-Tong Lin
- Cancer Science Institute of Singapore, National University of Singapore
- Xin-Yu Ke
- Cancer Science Institute of Singapore, National University of Singapore
- Jonathan W. Said
- Department of Pathology, UCLA Medical Center, University of California
- Jianxiang Chen
- Holistic Integrative Pharmacy Institutes, School of Medicine, Hangzhou Normal University
- Sigal Gery
- Department of Medicine, Cedars-Sinai Medical Center
- Ling-Wen Ding
- Cancer Science Institute of Singapore, National University of Singapore
- Yan-Yi Jiang
- Cancer Science Institute of Singapore, National University of Singapore
- Angela Pang
- National University Cancer Institute, National University Hospital
- Mark Edward Puhaindran
- National University Cancer Institute, National University Hospital
- Boon Cher Goh
- Cancer Science Institute of Singapore, National University of Singapore
- H. Phillip Koeffler
- Cancer Science Institute of Singapore, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-019-09257-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Liposarcoma (LPS) is a rare cancer that can acquire resistance to chemotherapy. Here, the authors map super-enhancers in LPS, finding BET-protein dependent mechanisms that can be targeted by a BET protein degrader, which also can overcome acquired resistance to chemotherapy in LPS.
