DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology

Hao Xiong; Hao Xiong; Fuzhou Hua; Fuzhou Hua; Yao Dong; Yue Lin; Yue Lin; Jun Ying; Jun Ying; Jie Liu; Jie Liu; Xifeng Wang; Lieliang Zhang; Lieliang Zhang; Jing Zhang

doi:10.3389/fnagi.2022.933015

Frontiers in Aging Neuroscience (Sep 2022)

DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology

Hao Xiong,
Hao Xiong,
Fuzhou Hua,
Fuzhou Hua,
Yao Dong,
Yue Lin,
Yue Lin,
Jun Ying,
Jun Ying,
Jie Liu,
Jie Liu,
Xifeng Wang,
Lieliang Zhang,
Lieliang Zhang,
Jing Zhang

Affiliations

Hao Xiong: Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
Hao Xiong: Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
Fuzhou Hua: Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
Fuzhou Hua: Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
Yao Dong: Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China
Yue Lin: Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
Yue Lin: Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
Jun Ying: Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
Jun Ying: Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
Jie Liu: Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
Jie Liu: Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
Xifeng Wang: Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China
Lieliang Zhang: Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
Lieliang Zhang: Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
Jing Zhang: Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China

DOI: https://doi.org/10.3389/fnagi.2022.933015
Journal volume & issue: Vol. 14

Abstract

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Aging is the continuous degradation of biological function and structure with time, and cellular senescence lies at its core. DNA damage response (DDR) can activate Ataxia telangiectasia-mutated serine/threonine kinase (ATM) and Rad3-related serine/threonine kinase (ATR), after which p53 activates p21, stopping the cell cycle and inducing cell senescence. GATA4 is a transcription factor that plays an important role in the development of many organs, such as the heart, testis, ovary, foregut, liver, and ventral pancreas. Studies have shown that GATA4 can also contribute to the DDR, leading to aging. Consistently, there is also evidence that the GATA4 signaling pathway is associated with aging-related diseases, including atherosclerosis and heart failure. This paper reviews the relationship between GATA4, DDR, and cellular senescence, as well as its effect on aging-related diseases.

Published in Frontiers in Aging Neuroscience

ISSN: 1663-4365 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/aging-neuroscience

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