Nature Communications (Nov 2022)
A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation
- Hiromi Watari,
- Hiromu Kageyama,
- Nami Masubuchi,
- Hiroya Nakajima,
- Kako Onodera,
- Pamela J. Focia,
- Takumi Oshiro,
- Takashi Matsui,
- Yoshio Kodera,
- Tomohisa Ogawa,
- Takeshi Yokoyama,
- Makoto Hirayama,
- Kanji Hori,
- Douglas M. Freymann,
- Misa Imai,
- Norio Komatsu,
- Marito Araki,
- Yoshikazu Tanaka,
- Ryuichi Sakai
Affiliations
- Hiromi Watari
- Graduate School of Fisheries Sciences, Hokkaido University
- Hiromu Kageyama
- Graduate School of Life Sciences, Tohoku University
- Nami Masubuchi
- Laboratory for the Development of Therapies against MPN, Juntendo University Graduate School of Medicine
- Hiroya Nakajima
- Graduate School of Fisheries Sciences, Hokkaido University
- Kako Onodera
- Graduate School of Life Sciences, Tohoku University
- Pamela J. Focia
- Department of Biochemistry & Molecular Genetics, Feinberg School of Medicine, Northwestern University
- Takumi Oshiro
- Department of Physics, School of Science, Kitasato University
- Takashi Matsui
- Department of Physics, School of Science, Kitasato University
- Yoshio Kodera
- Department of Physics, School of Science, Kitasato University
- Tomohisa Ogawa
- Graduate School of Life Sciences, Tohoku University
- Takeshi Yokoyama
- Graduate School of Life Sciences, Tohoku University
- Makoto Hirayama
- Graduate School of Integrated Sciences for Life, Hiroshima University
- Kanji Hori
- Graduate School of Integrated Sciences for Life, Hiroshima University
- Douglas M. Freymann
- Department of Biochemistry & Molecular Genetics, Feinberg School of Medicine, Northwestern University
- Misa Imai
- Laboratory for the Development of Therapies against MPN, Juntendo University Graduate School of Medicine
- Norio Komatsu
- Laboratory for the Development of Therapies against MPN, Juntendo University Graduate School of Medicine
- Marito Araki
- Laboratory for the Development of Therapies against MPN, Juntendo University Graduate School of Medicine
- Yoshikazu Tanaka
- Graduate School of Life Sciences, Tohoku University
- Ryuichi Sakai
- Graduate School of Fisheries Sciences, Hokkaido University
- DOI
- https://doi.org/10.1038/s41467-022-34921-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
The mode of cytokine receptor activation is diverse. Here, the authors find that the marine-sponge derived lectin ThC, a bivalent sugar binding protein, activates human cytokine receptor MPL. This mode of action resembles the pathogenic activation of MPL by mutant molecular chaperon calreticulin in hematologic malignancies.
