OncoTargets and Therapy (Mar 2018)
Prognostic value of increased integrin-beta 1 expression in solid cancers: a meta-analysis
Abstract
Quanwu Sun,1,* Chuan Zhou,2,* Ruofei Ma,3 Qianhong Guo,4 Haiyun Huang,1 Jie Hao,1 Hong Liu,1 Rong Shi,1 Bo Liu1 1Department of Breast Surgery, The People’s Hospital of Gansu Province, Lanzhou City, Gansu, China; 2Department of Urology/Institute of Urology, West China School of Medicine/West China Hospital, Sichuan University, Chengdu, China; 3Department of Abdominal Surgery, Gansu Tumor Hospital, Lanzhou City, Gansu, China; 4Department of Oncological Surgery, The First People’s Hospital of Tianshui City, Tianshui City, Gansu, China *These authors contributed equally to this work Abstract: Integrin-beta 1 (ITGB1) is aberrantly overexpressed or downregulated in solid cancers; however, its prognostic value remains controversial. Therefore, we conducted a meta-analysis to explore whether ITGB1 expression is correlated with overall survival (OS) and the clinicopathological characteristics of patients with solid cancers. We systematically searched the PubMed, Embase, and Web of Science databases for eligible studies published up to June 1, 2017. In total, 22 studies involving 3,666 patients were included. A sensitivity analysis was performed to assess the validity and reliability of the pooled OS. Among the 22 studies, 7 focused on lung cancer, 3 focused on colorectal cancer, 6 focused on breast cancer, 3 involved melanoma, and 3 involved pancreatic cancer. The pooled results showed that high ITGB1 expression was significantly associated with worse OS in lung cancer (pooled hazard ratio [HR]=1.78, 95% CI: 1.19–2.65, p<0.05) and breast cancer (pooled HR=1.88, 95% CI: 1.46–2.42, p<0.01). In addition, a significant association was observed between high ITGB1 expression and disease-free survival in breast cancer (pooled HR=1.63, 95% CI: 1.17–2.25, p<0.001) and pancreatic cancer (pooled HR=2.49, 95% CI: 1.35–4.61, p<0.001). However, high ITGB1 expression was not related to OS in colorectal cancer, pancreatic cancer, or melanoma. The pooled HRs used to evaluate the prognostic value of increased ITGB1 expression in lung cancer, breast cancer, and pancreatic cancer were not significantly altered, which indicates that the pooled results were robust. The results of this study indicate that the prognostic value of decreased ITGB1 expression varies among solid cancers. Keywords: ITGB1, solid cancer, prognosis, meta-analysis