Proinflammatory profile in the skin of Parkinson's disease patients with and without pain.

Abstract

BackgroundPain is a common non-motor symptom of Parkinson`s disease (PD), however, its pathomechanism remains elusive.ObjectiveWe aimed to investigate the local gene expression of selected proinflammatory mediators in patients with PD and correlated our data with patients`pain phenotype.MethodsWe recruited 30 patients with PD and 30 healthy controls. Pain intensity of patients was assessed using the Numeric Rating Scale (NRS) and patients were stratified into PD pain (NRS≥4) and PD No Pain (NRSResultsPatients with PD had lower distal IENFD compared to healthy controls. In skin samples, IL-2 (pConclusionsOur data suggest the occurrence of a local, peripheral inflammatory response in the skin in PD, but do not support this being a relevant factor contributing to pain in PD.