Thermal Cleavage of the Fmoc Protection Group

Abstract

The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.

Keywords

• Dibenzofulvene
• Fmoc protection group
• High-temperature nmr
• Peptide synthesis
• Thermal cleavage