Nature Communications (Mar 2021)
Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance
- Huan Cao,
- Aristotelis Antonopoulos,
- Sadie Henderson,
- Heather Wassall,
- John Brewin,
- Alanna Masson,
- Jenna Shepherd,
- Gabriela Konieczny,
- Bhinal Patel,
- Maria-Louise Williams,
- Adam Davie,
- Megan A. Forrester,
- Lindsay Hall,
- Beverley Minter,
- Dimitris Tampakis,
- Michael Moss,
- Charlotte Lennon,
- Wendy Pickford,
- Lars Erwig,
- Beverley Robertson,
- Anne Dell,
- Gordon D. Brown,
- Heather M. Wilson,
- David C. Rees,
- Stuart M. Haslam,
- J. Alexandra Rowe,
- Robert N. Barker,
- Mark A. Vickers
Affiliations
- Huan Cao
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Aristotelis Antonopoulos
- Department of Life Sciences, Imperial College London
- Sadie Henderson
- Scottish National Blood Transfusion Service
- Heather Wassall
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- John Brewin
- Department of Haematology, King’s College Hospital
- Alanna Masson
- Department of Haematology, Aberdeen Royal Infirmary
- Jenna Shepherd
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Gabriela Konieczny
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Bhinal Patel
- Department of Life Sciences, Imperial College London
- Maria-Louise Williams
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Adam Davie
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Megan A. Forrester
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Lindsay Hall
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Beverley Minter
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Dimitris Tampakis
- Centre for Biological Engineering, School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University and Division of Cancer Studies, King’s College London
- Michael Moss
- Scottish National Blood Transfusion Service
- Charlotte Lennon
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Wendy Pickford
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Lars Erwig
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Beverley Robertson
- Department of Life Sciences, Imperial College London
- Anne Dell
- Department of Haematology, King’s College Hospital
- Gordon D. Brown
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Heather M. Wilson
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- David C. Rees
- Department of Haematology, King’s College Hospital
- Stuart M. Haslam
- Department of Life Sciences, Imperial College London
- J. Alexandra Rowe
- Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh
- Robert N. Barker
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Mark A. Vickers
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- DOI
- https://doi.org/10.1038/s41467-021-21814-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Red blood cells (RBCs) are phagocytosed in the spleen in sickle cell disease and malaria. Here, Cao et al. show that high mannose N-glycans, exposed on diseased or oxidized RBC surfaces, bind mannose receptor CD206 on host cells, mediating phagocytosis.
