Indian Journal of Ophthalmology (Jan 2012)
Desferrioxamine-related ocular toxicity: A case report
- Sumu Simon,
- Paul A Athanasiov,
- Rajeev Jain,
- Grant Raymond,
- Jagjit S Gilhotra
Affiliations
- Sumu Simon
- Paul A Athanasiov
- Rajeev Jain
- Grant Raymond
- Jagjit S Gilhotra
- DOI
- https://doi.org/10.4103/0301-4738.98714
- Journal volume & issue
-
Vol. 60,
no. 4
pp. 315 – 317
Abstract
A 29-year-old lady receiving repeated blood transfusions for β thalassemia since childhood, presented with rapidly deteriorating symptoms of night blindness and peripheral visual field loss. She was recently commenced on high-dose intravenous desferrioxamine for reducing the systemic iron overload. Clinical and investigative findings were consistent with desferrioxamine-related pigmentary retinopathy and optic neuropathy. Recovery was partial following cessation of desferrioxamine. This report highlights the ocular side-effects of desferrioxamine mesylate and the need to be vigilant in patients on high doses of desferrioxamine.
Keywords
- Apoptosis
- glaucoma
- intraocular pressure
- retinal ganglion cells
- retinal ischemia
- tumor necrosis factor-alpha
- Branch retinal vein occlusion
- laser
- Lucentis
- macular edema
- Microbial etiology
- mucopurulent keratitis
- suppurative keratitis
- Intraoperative application of mitomycin C
- mitomycin C
- postoperative complications
- preoperative subconjunctival injection
- recurrence rate
- recurrent pterygium
- Cataract
- inflammation
- mydriasis
- prevention and control
- surgery
- Cross-cylinder technique
- photoastigmatic refractive keratectomy
- refractive surgery
- ′BARC I-125 Ocu-Prosta seeds′
- choroidal melanoma
- plaque brachytherapy
- retinoblastoma
- vasoproliferative tumors
- Asian Indian
- Amaurosis
- amaurosis hemianopia
- capsulolenticular cataract
- conjunctiva
- lenticular cataract
- leukoma
- eye lid
- ophthalmia chronica
- ophthalmic purulentis
- Interpretation
- magnetic resonance imaging
- orbit
- ophthalmology
- Antivascular endothelial growth factor
- intravitreal bevacizumab
- ocular inflammation
- Acute macular neuroretinopathy
- optical coherence tomography
- scotoma
- Desferrioxamine
- ocular toxicity
- optic neuropathy
- pigmentary retinopathy
