Aspirin-exacerbated respiratory disease: Update on medical management

Abstract

Aspirin-exacerbated respiratory disease (AERD) is frequently diagnosed in patients with severe type 2 airway inflammation presenting with nasal polyps and severe asthma. It has been associated with a recalcitrant course with high medical and surgical requirements. The advent of recent biological and other targeted treatments show promise in the medical management of patient with AERD. The goal of complete disease control where patients no longer require recurrent surgical procedures, systemic corticosteroid exposure and may live with a stable and relatively normal quality of life is now within reach. Further work is necessary to identify biomarkers predictive of treatment response.

Keywords

• Aspirin-exacerbated respiratory disease
• Samter syndrome
• Aspirin intolerant asthma
• Nasal polyposis
• Severe asthma