Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission

Himanish Ghosh; Luca Auguadri; Sereina Battaglia; Zahra Simone Thirouin; Khaled Zemoura; Simon Messner; Mario A. Acuña; Hendrik Wildner; Gonzalo E. Yévenes; Andrea Dieter; Hiroshi Kawasaki; Michael O. Hottiger; Hanns Ulrich Zeilhofer; Jean-Marc Fritschy; Shiva K. Tyagarajan

doi:10.1038/ncomms13365

Nature Communications (Nov 2016)

Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission

Himanish Ghosh,
Luca Auguadri,
Sereina Battaglia,
Zahra Simone Thirouin,
Khaled Zemoura,
Simon Messner,
Mario A. Acuña,
Hendrik Wildner,
Gonzalo E. Yévenes,
Andrea Dieter,
Hiroshi Kawasaki,
Michael O. Hottiger,
Hanns Ulrich Zeilhofer,
Jean-Marc Fritschy,
Shiva K. Tyagarajan

Affiliations

Himanish Ghosh: Institute of Pharmacology and Toxicology, University of Zurich
Luca Auguadri: Institute of Pharmacology and Toxicology, University of Zurich
Sereina Battaglia: Institute of Pharmacology and Toxicology, University of Zurich
Zahra Simone Thirouin: Institute of Pharmacology and Toxicology, University of Zurich
Khaled Zemoura: Institute of Pharmacology and Toxicology, University of Zurich
Simon Messner: Department of Molecular Mechanisms of Disease, University of Zurich
Mario A. Acuña: Institute of Pharmacology and Toxicology, University of Zurich
Hendrik Wildner: Institute of Pharmacology and Toxicology, University of Zurich
Gonzalo E. Yévenes: Institute of Pharmacology and Toxicology, University of Zurich
Andrea Dieter: Institute of Pharmacology and Toxicology, University of Zurich
Hiroshi Kawasaki: Department of Molecular and Systems Neurobiology, Graduate School of Medicine, The University of Tokyo
Michael O. Hottiger: Department of Molecular Mechanisms of Disease, University of Zurich
Hanns Ulrich Zeilhofer: Institute of Pharmacology and Toxicology, University of Zurich
Jean-Marc Fritschy: Institute of Pharmacology and Toxicology, University of Zurich
Shiva K. Tyagarajan: Institute of Pharmacology and Toxicology, University of Zurich

DOI: https://doi.org/10.1038/ncomms13365
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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Gephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic transmission that involve acetylation, SUMOylation and phosphorylation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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