Nature Communications (Oct 2020)

Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

  • Nuno Apóstolo,
  • Samuel N. Smukowski,
  • Jeroen Vanderlinden,
  • Giuseppe Condomitti,
  • Vasily Rybakin,
  • Jolijn ten Bos,
  • Laura Trobiani,
  • Sybren Portegies,
  • Kristel M. Vennekens,
  • Natalia V. Gounko,
  • Davide Comoletti,
  • Keimpe D. Wierda,
  • Jeffrey N. Savas,
  • Joris de Wit

DOI
https://doi.org/10.1038/s41467-020-18956-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 21

Abstract

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Mossy fiber synapses are key in CA3 microcircuit function. Here, the authors profile the mossy fiber synapse proteome and cell-surface interactome. They uncover a diverse repertoire of cell-surface proteins and identify the receptor IgSF8 as a regulator of CA3 microcircuit connectivity and function.