Preparation of Liposomes Coated Superparamagnetic Iron Oxide Nanoparticles for Targeting and Imaging Brain Glioma

Weijia Chen; Yingtian Xu; Dicheng Yang; Ping Wang; Yan Xu; Jun Zhu; Daxiang Cui

doi:10.5101/nbe.v14i1.p71-80

Nano Biomedicine and Engineering (Mar 2022)

Preparation of Liposomes Coated Superparamagnetic Iron Oxide Nanoparticles for Targeting and Imaging Brain Glioma

Weijia Chen,
Yingtian Xu,
Dicheng Yang,
Ping Wang,
Yan Xu,
Jun Zhu,
Daxiang Cui

Affiliations

Weijia Chen: National Engineering Research Center for Nanotechnology, Shanghai, China
Yingtian Xu: National Engineering Research Center for Nanotechnology, Shanghai, China
Dicheng Yang: National Engineering Research Center for Nanotechnology, Shanghai, China
Ping Wang: National Engineering Research Center for Nanotechnology, Shanghai, China
Yan Xu: National Engineering Research Center for Nanotechnology, Shanghai, China
Jun Zhu: National Engineering Research Center for Nanotechnology, Shanghai, China
Daxiang Cui: Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China

DOI: https://doi.org/10.5101/nbe.v14i1.p71-80
Journal volume & issue: Vol. 14, no. 1
pp. 71 – 80

Abstract

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Effective and specific diagnostic imaging of brain glioma remains a challenge. Magnetic nanoparticles are actively being developed as contrast agents for diagnosis of tumor. In this work, we developed the targeted magnetic nanoparticles as T1-positive magnetic resonance imaging (MRI) contrast agents. Zn-doped Fe3O4 NPs were synthesized by solvothermal method, coated with liposome and conjugated to a tumor-penetrating peptide (RGERPPR). The effect of zinc doping on the magnetic properties of Fe3O4 nanoparticles was studied. Zn0.4Fe2.6O4-PEG nanoparticles exhibited T1 MR contrast enhancement. Cytotoxicity assay indicated that nanoparticles have good biocompatibility and low toxicity. And the in vitro cellular uptake assays on U87 cells confirmed that the conjugation of RGERPPR increased the uptake of the Zn0.4Fe2.6O4 NPs. In vivo MR imaging showed the contrast enhance of U87 brain glioma in rat model after injection.

Published in Nano Biomedicine and Engineering

ISSN: 2097-3837 (Print); 2150-5578 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Science: Biology (General); Medicine
Website: https://www.sciopen.com/journal/2150-5578

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