CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence

Clément Crochemore; Cristina Fernández-Molina; Benjamin Montagne; Audrey Salles; Miria Ricchetti

doi:10.1038/s41467-019-13314-y

Nature Communications (Dec 2019)

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence

Clément Crochemore,
Cristina Fernández-Molina,
Benjamin Montagne,
Audrey Salles,
Miria Ricchetti

Affiliations

Clément Crochemore: Institut Pasteur, Stem Cells and Development, Department of Developmental and Stem Cell Biology
Cristina Fernández-Molina: Institut Pasteur, Stem Cells and Development, Department of Developmental and Stem Cell Biology
Benjamin Montagne: Institut Pasteur, Stem Cells and Development, Department of Developmental and Stem Cell Biology
Audrey Salles: Institut Pasteur, UTechS Photonic BioImaging PBI (Imagopole), Centre de Recherche et de Ressources Technologiques C2RT
Miria Ricchetti: Institut Pasteur, Stem Cells and Development, Department of Developmental and Stem Cell Biology

DOI: https://doi.org/10.1038/s41467-019-13314-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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Senescence of metabolically active cells is a process linked to ageing. Here the authors reveal that CSB is required to block replicative senescence, and epigenetic control of CSB downregulation triggers proliferative arrest in a p21-dependent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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