Data on the effects of N-cadherin perturbation on the expression of type II cadherin proteins and major signaling pathways

Abstract

This article contains data related to the research article entitled, “A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices” (Rogers et. al., 2018) [1]. The data presented here include (1) proximity ligation assays using antibodies that recognize type I cadherins (N-cadherin and E-cadherin) co-incubated with antibodies against type II cadherins (Cadherin-6B and Cadherin-11) to test heterotypic interactions in vivo; (2) expression of Cadherin-6B and Cadherin-7 after electroporation with full length N-cadherin and N-cadherin translation-blocking morpholino; and (3) expression of WNT, Notch and TGF-β signaling reporters and effectors after loss of N-cadherin protein in chicken embryos.