Association of Factor V Leiden Mutation with Pediatric Acute lymphoblastic Leukemia in Kermanshah Province

Abstract

Introduction: Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. The risk of thrombophilia increases in patients with ALL during chemotherapy. The present study aimed to investigate the frequency of factor V Leiden (FVL) mutation in children with acute lymphoblastic leukemia and its possible association with ALL. Patients and Methods: We studied 92 patients with ALL and 249 healthy individuals from Kermanshah Province of Iran. Detection of FVL mutation was performed by PCR-RFLP using restriction enzymes of Mnl I. Results: The frequency of FVL G1691A polymorphism was 7.8% in patients compared to 3.2% in controls (p=0.052). There was a trend towards increased risk of ALL in the presence of FVL mutation [OR=2.54, 95% CI 0.9-7.2, p=0.08]. Conclusions: Our results indicated that the frequency of both thrombophilic mutation of FVL was higher in ALL patients from Kermanshah province compared to healthy individuals and FVL mutation tended to be associated with the increased risk of ALL. Further studies needed to evaluate the association between FVL mutation and the occurrence of thromboembolism in ALL patients.