PLoS ONE (Jan 2022)

Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study

  • Sandra Martín-Peláez,
  • Lluis Serra-Majem,
  • Naomi Cano-Ibáñez,
  • Miguel Ángel Martínez-González,
  • Jordi Salas-Salvadó,
  • Dolores Corella,
  • Camille Lassale,
  • Jose Alfredo Martínez,
  • Ángel M. Alonso-Gómez,
  • Julia Wärnberg,
  • Jesús Vioque,
  • Dora Romaguera,
  • José López-Miranda,
  • Ramón Estruch,
  • Francisco J. Tinahones,
  • José Lapetra,
  • Fernando Fernández-Aranda,
  • Aurora Bueno-Cavanillas,
  • Josep A. Tur,
  • Vicente Martín,
  • Xavier Pintó,
  • Miguel Delgado-Rodríguez,
  • Pilar Matía,
  • Josep Vidal,
  • Clotilde Vázquez,
  • Lidia Daimiel,
  • Emili Ros,
  • Estefanía Toledo,
  • Stephanie K. Nishi,
  • Jose V. Sorli,
  • Mireia Malcampo,
  • M. Ángeles Zulet,
  • Anaí Moreno-Rodríguez,
  • Raquel Cueto-Galán,
  • Diego Vivancos-Aparicio,
  • Antoni Colom,
  • Antonio García-Ríos,
  • Rosa Casas,
  • M Rosa Bernal-López,
  • Jose Manuel Santos-Lozano,
  • Zenaida Vázquez,
  • Carlos Gómez-Martínez,
  • Carolina Ortega-Azorín,
  • Jose Luís del Val,
  • Itziar Abete,
  • Amaia Goikoetxea-Bahon,
  • Elena Pascual,
  • Nerea Becerra-Tomás,
  • Juan J. Chillarón,
  • Almudena Sánchez-Villegas

Journal volume & issue
Vol. 17, no. 4

Abstract

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Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55–75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).