Nature Communications (Apr 2020)
Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction
- D. Julia Trembinski,
- Diewertje I. Bink,
- Kosta Theodorou,
- Janina Sommer,
- Ariane Fischer,
- Anke van Bergen,
- Chao-Chung Kuo,
- Ivan G. Costa,
- Christoph Schürmann,
- Matthias S. Leisegang,
- Ralf P. Brandes,
- Tijna Alekseeva,
- Boris Brill,
- Astrid Wietelmann,
- Christopher N. Johnson,
- Alexander Spring-Connell,
- Manuel Kaulich,
- Stanislas Werfel,
- Stefan Engelhardt,
- Marc N. Hirt,
- Kaja Yorgan,
- Thomas Eschenhagen,
- Luisa Kirchhof,
- Patrick Hofmann,
- Nicolas Jaé,
- Ilka Wittig,
- Nazha Hamdani,
- Corinne Bischof,
- Jaya Krishnan,
- Riekelt H. Houtkooper,
- Stefanie Dimmeler,
- Reinier A. Boon
Affiliations
- D. Julia Trembinski
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- Diewertje I. Bink
- Department of Physiology, VU University Medical Center
- Kosta Theodorou
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- Janina Sommer
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- Ariane Fischer
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- Anke van Bergen
- Department of Physiology, VU University Medical Center
- Chao-Chung Kuo
- Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen University
- Ivan G. Costa
- Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen University
- Christoph Schürmann
- Institute for Cardiovascular Physiology, Medical Faculty, Goethe University Frankfurt am Main
- Matthias S. Leisegang
- German Center for Cardiovascular Research (DZHK)
- Ralf P. Brandes
- German Center for Cardiovascular Research (DZHK)
- Tijna Alekseeva
- Georg Speyer Haus, Institute for Tumor Biology and Experimental Therapy
- Boris Brill
- Georg Speyer Haus, Institute for Tumor Biology and Experimental Therapy
- Astrid Wietelmann
- Max-Planck-Institute for Heart and Lung Research
- Christopher N. Johnson
- Division of Clinical Pharmacology, Vanderbilt University Medical Center
- Alexander Spring-Connell
- Department of Chemistry, Georgia State University
- Manuel Kaulich
- Institute of Biochemistry II, Goethe University
- Stanislas Werfel
- German Center for Cardiovascular Research (DZHK)
- Stefan Engelhardt
- German Center for Cardiovascular Research (DZHK)
- Marc N. Hirt
- German Center for Cardiovascular Research (DZHK)
- Kaja Yorgan
- German Center for Cardiovascular Research (DZHK)
- Thomas Eschenhagen
- German Center for Cardiovascular Research (DZHK)
- Luisa Kirchhof
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- Patrick Hofmann
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- Nicolas Jaé
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- Ilka Wittig
- German Center for Cardiovascular Research (DZHK)
- Nazha Hamdani
- Department of Physiology, VU University Medical Center
- Corinne Bischof
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- Jaya Krishnan
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- Riekelt H. Houtkooper
- Laboratory Genetic Metabolic Diseases, Academic Medical Center
- Stefanie Dimmeler
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- Reinier A. Boon
- Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main
- DOI
- https://doi.org/10.1038/s41467-020-15995-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Aging induces cardiovascular disease, but which RNA molecules control cardiac aging is poorly understood. Here the authors identified the aging-regulated non-coding RNA Sarrah, which controls cardiomyocyte survival and cardiac function by inducing cardioprotective genes.
