A novel compound isolated from Sclerochloa dura has anti-inflammatory effects

Bukhari Syed Majid; Feuerherm Astrid Jullumstrø; Tunset Hanna Maja; Isaksen Stian Moe; Sæther Mari; Thvedt Thor Håkon Krane; Gonzalez Susana Villa; Schmid Rudolf; Brunsvik Anders; Fuglseth Erik; Zlatković Bojan; Johansen Berit; Simić Nebojša

doi:10.2298/JSC150119055B

Journal of the Serbian Chemical Society (Jan 2016)

A novel compound isolated from Sclerochloa dura has anti-inflammatory effects

Bukhari Syed Majid,
Feuerherm Astrid Jullumstrø,
Tunset Hanna Maja,
Isaksen Stian Moe,
Sæther Mari,
Thvedt Thor Håkon Krane,
Gonzalez Susana Villa,
Schmid Rudolf,
Brunsvik Anders,
Fuglseth Erik,
Zlatković Bojan,
Johansen Berit,
Simić Nebojša

Affiliations

Bukhari Syed Majid: Norwegian University of Sciences and Technology, Department of Chemistry, Trondheim, Norway + COMSATS Institute of Information Technology, Department of Chemistry, Abbottabad, Pakistan
Feuerherm Astrid Jullumstrø: Norwegian University of Sciences and Technology, Department of Biology, Trondheim, Norway
Tunset Hanna Maja: Norwegian University of Sciences and Technology, Department of Biology, Trondheim, Norway
Isaksen Stian Moe: Norwegian University of Sciences and Technology, Department of Chemistry, Trondheim, Norway
Sæther Mari: Norwegian University of Sciences and Technology, Department of Biology, Trondheim, Norway
Thvedt Thor Håkon Krane: Norwegian University of Sciences and Technology, Department of Chemistry, Trondheim, Norway
Gonzalez Susana Villa: Norwegian University of Sciences and Technology, Department of Chemistry, Trondheim, Norway
Schmid Rudolf: Norwegian University of Sciences and Technology, Department of Chemistry, Trondheim, Norway
Brunsvik Anders: SINTEF Materials and Chemistry, Department of Mass Spectrometry, Trondheim, Norway
Fuglseth Erik: Norwegian University of Sciences and Technology, Technology transfer office, Trondheim, Norway
Zlatković Bojan: Department of Biology, Niš
Johansen Berit: Norwegian University of Sciences and Technology, Department of Biology, Trondheim, Norway
Simić Nebojša: Norwegian University of Sciences and Technology, Department of Chemistry, Trondheim, Norway

DOI: https://doi.org/10.2298/JSC150119055B
Journal volume & issue: Vol. 81, no. 1
pp. 1 – 12

Abstract

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The activation of PLA2 by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. By 6the cyclooxygenases (COX1/2) responsible for the enzymatic conversion of AA to eicosanoids, the non-steroidal anti-inflammatory drugs are effective in relieving the pain and discomfort of inflammation. By using AA release assay as a guide for biological and anti-inflammatory activity, novel compound 1-O-(3-O-linolenoyl-6-deoxy-6-sulfo-α-D-glucopyranosyl)-glycerol (1) together with five known compounds isovitexin, byzantionoside B, tricin 4’-O-(erythro-β-guaiacylglyceryl) ether 7-O-β-glucopyranoside, 1-O-feruloyl glycerol and tricin 7-glucoside were isolated from the methanol extract of the aerial parts of Sclerochloa dura using LC techniques (Sephadex LH-20 column chromatography, preparative HPLC and semi-preparative HPLC). All isolated compounds were identified using spectroscopic NMR spectroscopy and MS spectrometry. Novel compound (1) was found to be an effective inhibitor of AA release with an IC50 value of 0.09 ± 0.03 mg mL-1.

Published in Journal of the Serbian Chemical Society

ISSN: 0352-5139 (Print); 1820-7421 (Online)
Publisher: Serbian Chemical Society
Country of publisher: Serbia
LCC subjects: Science: Chemistry
Website: http://www.shd-pub.org.rs/index.php/JSCS

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