Nature Communications (Jul 2016)

Antimicrobial peptides trigger a division block in Escherichia coli through stimulation of a signalling system

  • Srujana S. Yadavalli,
  • Jeffrey N. Carey,
  • Rachel S. Leibman,
  • Annie I. Chen,
  • Andrew M. Stern,
  • Manuela Roggiani,
  • Andrew M. Lippa,
  • Mark Goulian

DOI
https://doi.org/10.1038/ncomms12340
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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The PhoQ/PhoP system regulates antimicrobial peptide defense in bacteria. Here the authors show that at sublethal concentrations of antimicrobial peptides, PhoPQ induces QueE, that then localizes to the divisome and blocks cell division independently of its function in queuosine biosynthesis.