Nature Communications (Oct 2020)

Identification of a pocket factor that is critical to Zika virus assembly

  • Nadia M. DiNunno,
  • Daniel J. Goetschius,
  • Anoop Narayanan,
  • Sydney A. Majowicz,
  • Ibrahim Moustafa,
  • Carol M. Bator,
  • Susan L. Hafenstein,
  • Joyce Jose

DOI
https://doi.org/10.1038/s41467-020-18747-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

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Here, the authors provide a 3.4 Å resolution structure of mature Zika virus (ZIKV) and identify two lipid moieties, coordinated by hydrophobic residues of the M and E transmembrane helices and between two helices of E protein, that play an essential role in the ZIKV assembly pathway.