Nature Communications (Jul 2021)
The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling
- Eui Jung Moon,
- Stephano S. Mello,
- Caiyun G. Li,
- Jen-Tsan Chi,
- Kaushik Thakkar,
- Jacob G. Kirkland,
- Edward L. Lagory,
- Ik Jae Lee,
- Anh N. Diep,
- Yu Miao,
- Marjan Rafat,
- Marta Vilalta,
- Laura Castellini,
- Adam J. Krieg,
- Edward E. Graves,
- Laura D. Attardi,
- Amato J. Giaccia
Affiliations
- Eui Jung Moon
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Stephano S. Mello
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Caiyun G. Li
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Jen-Tsan Chi
- Department of Molecular Genetics and Microbiology, Duke University
- Kaushik Thakkar
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Jacob G. Kirkland
- Department of Pathology, Department of Developmental Biology, Stanford University
- Edward L. Lagory
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Ik Jae Lee
- Department of Radiation Oncology, Yonsei Cancer Center
- Anh N. Diep
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Yu Miao
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Marjan Rafat
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Marta Vilalta
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Laura Castellini
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Adam J. Krieg
- Department of Obstetrics and Gynecology, Oregon Health and Sciences University
- Edward E. Graves
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Laura D. Attardi
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- Amato J. Giaccia
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University
- DOI
- https://doi.org/10.1038/s41467-021-24631-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Hypoxia plays a critical role in tumor progression including invasion and metastasis. Here, the authors screened several hypoxia inducible genes and identified the oncogenic role of MAFF in breast cancer metastasis and that it activates IL11/STAT3 pathway.
