Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions

Xinfu Zhang; Xinfu Zhang; Xinmin An

doi:10.3389/fmicb.2022.876174

Frontiers in Microbiology (Apr 2022)

Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions

Xinfu Zhang,
Xinfu Zhang,
Xinmin An

Affiliations

Xinfu Zhang: Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, GA, United States
Xinfu Zhang: Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Research Center of Tree breeding and Ecological Remediation, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China
Xinmin An: Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Research Center of Tree breeding and Ecological Remediation, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China

DOI: https://doi.org/10.3389/fmicb.2022.876174
Journal volume & issue: Vol. 13

Abstract

Read online

CRISPR-Cas systems acquire heritable defense memory against invading nucleic acids through adaptation. Type III CRISPR-Cas systems have unique and intriguing features of defense and are important in method development for Genetics research. We started to understand the common and unique properties of type III CRISPR-Cas adaptation in recent years. This review summarizes our knowledge regarding CRISPR-Cas adaptation with the emphasis on type III systems and discusses open questions for type III adaptation studies.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

About the journal

Abstract

Keywords