Nature Communications (Dec 2021)
Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity
- Nadège Zanou,
- Haikel Dridi,
- Steven Reiken,
- Tanes Imamura de Lima,
- Chris Donnelly,
- Umberto De Marchi,
- Manuele Ferrini,
- Jeremy Vidal,
- Leah Sittenfeld,
- Jerome N. Feige,
- Pablo M. Garcia-Roves,
- Isabel C. Lopez-Mejia,
- Andrew R. Marks,
- Johan Auwerx,
- Bengt Kayser,
- Nicolas Place
Affiliations
- Nadège Zanou
- Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne
- Haikel Dridi
- Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons
- Steven Reiken
- Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons
- Tanes Imamura de Lima
- Laboratory of Integrative Systems Physiology (LISP), École Polytechnique Fédérale de Lausanne (EPFL)
- Chris Donnelly
- Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne
- Umberto De Marchi
- Nestlé Research – École Polytechnique Fédérale de Lausanne (EPFL)
- Manuele Ferrini
- Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne
- Jeremy Vidal
- Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne
- Leah Sittenfeld
- Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons
- Jerome N. Feige
- Nestlé Research – École Polytechnique Fédérale de Lausanne (EPFL)
- Pablo M. Garcia-Roves
- Department of Physiological Sciences, School of Medicine and Health Sciences, University of Barcelona and Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet del Llobregat
- Isabel C. Lopez-Mejia
- Center for Integrative Genomics, University of Lausanne
- Andrew R. Marks
- Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons
- Johan Auwerx
- Laboratory of Integrative Systems Physiology (LISP), École Polytechnique Fédérale de Lausanne (EPFL)
- Bengt Kayser
- Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne
- Nicolas Place
- Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne
- DOI
- https://doi.org/10.1038/s41467-021-27422-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Ryanodine receptor type 1 (RyR1) are involved in skeletal muscle contraction. Here, the authors show that a transient calcium leak in response to exercise-induced post translational modifications of RyR1 causes mitochondrial remodeling to improve respiration.
