Biochemical changes of synovial fluid in patients with osteoporosis of knee joint of various etiology

Abstract

The aim of this study was to perform comparative analysis of biochemical composition of synovial fluid in patients with osteoarthrosis of various etiology. Studies were conducted on samples of synovial fluid of patients which were divided into two groups. Thefirstgroup consisted of 16 patients with patellofemoral arthrosis of the 2nd stage, the second group included 54 patients with bilateral gonarthrosis. The samples of synovial fluid of 11 cadavers of suddenly dead people of both sexes (4 men and 7 women) of 23-79 years who didn't have articular pathology registered by an expert were considered as a norm. Conducted study testifies significant imbalance of prooxidant and antioxidant processes in the synovial fluid and development of oxidative stress the intensity of which depends on the severity of the pathological process but is regardless to its etiology.

Keywords

• peroxidation
• synovial fluid
• osteoarthrosis
• patellofemoral arthrosis