The Zn-finger of <i>Saccharomyces cerevisiae</i> Rad18 and its adjacent region mediate interaction with Rad5

Abstract

AbstractDNA damages that hinder the movement of the replication complex can ultimately lead to cell death. To avoid that, cells possess several DNA damage bypass mechanisms. The Rad18 ubiquitin ligase controls error-free and mutagenic pathways that help the replication complex to bypass DNA lesions by monoubiquitylating PCNA at stalled replication forks. In Saccharomyces cerevisiaeRAD18in vivo