Clinical Ophthalmology (Feb 2021)
Efficacy of Pars Plana Vitrectomy with Internal Limiting Membrane Peeling for Treatment of Large Idiopathic Full-Thickness Macular Holes
Abstract
Suthasinee Sinawat,1 Sukita Jumpawong,1 Tanapat Ratanapakorn,1 Chavakij Bhoomibunchoo,1 Yosanan Yospaiboon,1 Supat Sinawat2 1KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCorrespondence: Suthasinee Sinawat; Yosanan YospaiboonKKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, 123 Mittraparb Highway, Khon Kaen, 40002, ThailandTel +66 43 348383Email [email protected]; [email protected]: To evaluate anatomical and visual outcomes of pars plana vitrectomy (PPV) with internal limiting membrane peeling (ILMP) in large idiopathic full-thickness macular holes (FTMH). Predictive factors also formed part of the study.Patients and Methods: A retrospective review of medical charts and optical coherence tomography images of patients with large idiopathic FTMH (≥ 400 μm) was conducted.Results: One hundred and fifty-eight eyes of 155 patients with a mean age of 62.94± 7.50 years were included in the study. Mean preoperative visual acuity (VA) was 1.26± 0.36 logMAR. Mean preoperative minimum linear diameter (MLD) and basal linear diameter (BLD) were 644.89± 136.85 μm and 1208.11± 307.14 μm, respectively. At 12 weeks postoperative follow-up, FTMH closure rate was 61.39% and mean postoperative BCVA was 0.92± 0.36 logMAR. Multivariate logistic regression analyses showed the anatomical outcome was significantly associated with BLD ≤ 1200 μm, preoperative vitreomacular interface (VMI) disorder and extended ILMP (a radius of 2 disc diameters), whereas only postoperative ellipsoid loss ≤ 500 μm was significantly associated with visual outcome. In subgroup analyses, the large FTMH group (400– 600 μm) had significantly better results in closure rate (70.97% vs 55.21%, P = 0.047) and visual results (P = 0.031) than the extra-large FTMH group (> 600 μm).Conclusion: PPV with conventional ILMP provided relatively low closure rate in large FTMH. Surgical success was significantly associated with BLD ≤ 1200 μm, no preoperative VMI abnormality, extended ILMP and postoperative ellipsoid defect ≤ 500 μm. Therefore, we suggest the extended ILMP if conventional ILMP technique is used. The large FTMH group had significantly better surgical outcomes than the extra-large group, so there is a need for reclassification of large FTMH.Keywords: full-thickness macular hole, internal limiting membrane peeling, conventional, complete flap, large macular hole
