The Hemoglobin-Red Cell Distribution Width and Neutrophil -Lymphocyte Ratio in Predicting Lamina Propria Invasion in Bladder Tumors?

Abstract

Objective: To investigate the importance of the Hemoglobin/Red cell distribution width ratio (Hb/RDW) and Neutrophil/Lymphocyte ratio (NLR) in predicting bladder lamina propria invasion before transurethral resection in non-muscular invasive bladder cancer (NMIBC) patients Methods: The data of the patients whose pathology after transurethral resection of the bladder was NMIBC between January 2010 and June 2016 were evaluated retrospectively. Group 1 had Ta (mucosa involvement) and Group 2 had T1 (submucosa involvement) lesions. The age, gender, tumor size and number of tumors of the patients were identified. The preoperative blood leucocyte (WBC), hemoglobin (Hb), neutrophil (N), lymphocyte (L), monocyte (M), platelet (PLT), mean platelet volume (MPV), and red cell distribution width (RDW) values were identified and the NLR, PLR, LMR values calculated. The Hb/RDW ratio was determined. Results: A total of 369 patients were evaluated. The mean age was similar between groups. Group 1 (Ta) consisted of 219 patients (66.3±10.7 years) and Group 2 (T1) 150 patients (66.9±10.4 years) (p=0.638). NLR was higher in Group 2 than Group 1 (2.4 (1.5) and 2.2 (1.5), respectively, p=0.042) and this difference was statistically significant. The Hb/RDW ratio in Group 2 was lower than in Group 1 (0.89±21 and 0.94±19, respectively, p=0.019) and this difference was statistically significant. Conclusion: We believe that a decrease in the Hb/RDW ratio and increase in NLR, which can be easily determined from the peripheral blood in the preoperative period, can be associated with lamina propria invasion (T1). These studies should be supported with prospective large series.

Keywords

• non-muscular invasive bladder cancer
• hemoglobin-red cell distribution width ratio
• neutrophil-lymphocyte ratio
• lamina propria invasion