Pathomechanisms of AERD—Recent Advances

Annina Lyly; Annina Lyly; Tanya M. Laidlaw; Marie Lundberg

doi:10.3389/falgy.2021.734733

Frontiers in Allergy (Sep 2021)

Pathomechanisms of AERD—Recent Advances

Annina Lyly,
Annina Lyly,
Tanya M. Laidlaw,
Marie Lundberg

Affiliations

Annina Lyly: Department of Otorhinolaryngology – Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Annina Lyly: Inflammation Center, Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Tanya M. Laidlaw: Department of Medicine, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States
Marie Lundberg: Department of Otorhinolaryngology – Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

DOI: https://doi.org/10.3389/falgy.2021.734733
Journal volume & issue: Vol. 2

Abstract

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The pathomechanisms behind NSAID-exacerbated respiratory disease are complex and still largely unknown. They are presumed to involve genetic predisposition and environmental triggers that lead to dysregulation of fatty acid and lipid metabolism, altered cellular interactions involving transmetabolism, and continuous and chronic inflammation in the respiratory track. Here, we go through the recent advances on the topic and sum up the current understanding of the background of this illness that broadly effects the patients' lives.

Published in Frontiers in Allergy

ISSN: 2673-6101 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.frontiersin.org/journals/allergy

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