Nature Communications (Nov 2022)
Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
- Seref Gul,
- Yasemin Kubra Akyel,
- Zeynep Melis Gul,
- Safak Isin,
- Onur Ozcan,
- Tuba Korkmaz,
- Saba Selvi,
- Ibrahim Danis,
- Ozgecan Savlug Ipek,
- Fatih Aygenli,
- Ali Cihan Taskin,
- Büşra Aytül Akarlar,
- Nurhan Ozlu,
- Nuri Ozturk,
- Narin Ozturk,
- Durişehvar Özer Ünal,
- Mustafa Guzel,
- Metin Turkay,
- Alper Okyar,
- Ibrahim Halil Kavakli
Affiliations
- Seref Gul
- Department of Chemical and Biological Engineering, Koc University
- Yasemin Kubra Akyel
- Faculty of Pharmacy, Department of Pharmacology, İstanbul University
- Zeynep Melis Gul
- Department of Molecular Biology and Genetics, Koc University
- Safak Isin
- Department of Molecular Biology and Genetics, Koc University
- Onur Ozcan
- Department of Molecular Biology and Genetics, Koc University
- Tuba Korkmaz
- Department of Molecular Biology and Genetics, Gebze Technical University, Gebze
- Saba Selvi
- Department of Molecular Biology and Genetics, Gebze Technical University, Gebze
- Ibrahim Danis
- Faculty of Pharmacy, Department of Analytical Chemistry, İstanbul University
- Ozgecan Savlug Ipek
- Regenerative and Restorative Medicine Research Center (REMER), İstanbul Medipol University
- Fatih Aygenli
- Department of Molecular Biology and Genetics, Gebze Technical University, Gebze
- Ali Cihan Taskin
- Animal Research Facility, Research Center for Translational Medicine, Koc University, Rumelifeneri yolu
- Büşra Aytül Akarlar
- Department of Molecular Biology and Genetics, Koc University
- Nurhan Ozlu
- Department of Molecular Biology and Genetics, Koc University
- Nuri Ozturk
- Department of Molecular Biology and Genetics, Gebze Technical University, Gebze
- Narin Ozturk
- Faculty of Pharmacy, Department of Pharmacology, İstanbul University
- Durişehvar Özer Ünal
- Faculty of Pharmacy, Department of Analytical Chemistry, İstanbul University
- Mustafa Guzel
- Regenerative and Restorative Medicine Research Center (REMER), İstanbul Medipol University
- Metin Turkay
- Department of Industrial Engineering, Koc University
- Alper Okyar
- Faculty of Pharmacy, Department of Pharmacology, İstanbul University
- Ibrahim Halil Kavakli
- Department of Chemical and Biological Engineering, Koc University
- DOI
- https://doi.org/10.1038/s41467-022-34582-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Cryptochromes are transcriptional regulators of the circadian clock in mammals, and genetic loss of cryptochromes reduces p53-associated cancer risk in mice. Here the authors report the discovery of small molecule M47, which destabilizes cryptochrome 1 and extends the lifespan of p53 knock-out mice.
