Nature Communications (Dec 2020)
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway
- Sarah E. Smith,
- Xiaoying Chen,
- Lindsey M. Brier,
- Jonathan R. Bumstead,
- Nicholas R. Rensing,
- Alison E. Ringel,
- Haewon Shin,
- Anna Oldenborg,
- Jan R. Crowley,
- Annie R. Bice,
- Krikor Dikranian,
- Joseph E. Ippolito,
- Marcia C. Haigis,
- Thomas Papouin,
- Guoyan Zhao,
- Michael Wong,
- Joseph P. Culver,
- Azad Bonni
Affiliations
- Sarah E. Smith
- Department of Neuroscience, Washington University School of Medicine
- Xiaoying Chen
- Department of Neuroscience, Washington University School of Medicine
- Lindsey M. Brier
- MD-PhD Program, Washington University School of Medicine
- Jonathan R. Bumstead
- Department of Radiology, Washington University School of Medicine
- Nicholas R. Rensing
- Department of Neurology, Washington University School of Medicine
- Alison E. Ringel
- Department of Cell Biology, Blavatnik Institute, Harvard Medical School
- Haewon Shin
- Department of Neuroscience, Washington University School of Medicine
- Anna Oldenborg
- Department of Neuroscience, Washington University School of Medicine
- Jan R. Crowley
- Department of Internal Medicine, Washington University School of Medicine
- Annie R. Bice
- Department of Radiology, Washington University School of Medicine
- Krikor Dikranian
- Department of Neuroscience, Washington University School of Medicine
- Joseph E. Ippolito
- Department of Radiology, Washington University School of Medicine
- Marcia C. Haigis
- Department of Cell Biology, Blavatnik Institute, Harvard Medical School
- Thomas Papouin
- Department of Neuroscience, Washington University School of Medicine
- Guoyan Zhao
- Department of Neuroscience, Washington University School of Medicine
- Michael Wong
- Department of Neurology, Washington University School of Medicine
- Joseph P. Culver
- Department of Radiology, Washington University School of Medicine
- Azad Bonni
- Department of Neuroscience, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19915-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Mutations of α2-Na/K ATPase can cause familial hemiplegic migraine via unclear mechanisms. Here, the authors show that deletion of α2-Na/K ATPase in astrocytes results in gene expression and metabolic changes leading to cortical spreading depression and episodic transient motor paralysis in mice.
