Nature Communications (Aug 2017)
Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
- Issaka Yougbaré,
- Wei-She Tai,
- Darko Zdravic,
- Brigitta Elaine Oswald,
- Sean Lang,
- Guangheng Zhu,
- Howard Leong-Poi,
- Dawei Qu,
- Lisa Yu,
- Caroline Dunk,
- Jianhong Zhang,
- John G. Sled,
- Stephen J. Lye,
- Jelena Brkić,
- Chun Peng,
- Petter Höglund,
- B. Anne Croy,
- S. Lee Adamson,
- Xiao-Yan Wen,
- Duncan J. Stewart,
- John Freedman,
- Heyu Ni
Affiliations
- Issaka Yougbaré
- Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
- Wei-She Tai
- Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
- Darko Zdravic
- Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
- Brigitta Elaine Oswald
- Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
- Sean Lang
- Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
- Guangheng Zhu
- Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
- Howard Leong-Poi
- Division of Cardiology, St. Michael’s Hospital, University of Toronto
- Dawei Qu
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Lisa Yu
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Caroline Dunk
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Jianhong Zhang
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- John G. Sled
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Stephen J. Lye
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Jelena Brkić
- Department of Biology, York University
- Chun Peng
- Department of Biology, York University
- Petter Höglund
- Department of Medicine Huddinge, Center for Hematology and Regenerative Medicine (HERM), Karolinska Institutet
- B. Anne Croy
- Department of Biomedical and Molecular Sciences, Queen’s University
- S. Lee Adamson
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Xiao-Yan Wen
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
- Duncan J. Stewart
- Ottawa Hospital Research Institute
- John Freedman
- Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
- Heyu Ni
- Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
- DOI
- https://doi.org/10.1038/s41467-017-00269-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a gestational disease caused by maternal immune responses against fetal platelets. Using a FNAIT mouse model and human trophoblast cell lines, here the authors show that uterine natural killer cell-mediated trophoblast apoptosis contributes to FNAIT pathogenesis.
