Advances in Radiation Oncology (Mar 2022)

Dynamic Contrast-enhanced and Diffusion-weighted Magnetic Resonance Imaging for Response Evaluation After Single-Dose Ablative Neoadjuvant Partial Breast Irradiation

  • Jeanine E. Vasmel, MD,
  • Maureen L. Groot Koerkamp, MSc,
  • Stefano Mandija, PhD,
  • Wouter B. Veldhuis, PhD,
  • Maaike R. Moman, PhD,
  • Martijn Froeling, PhD,
  • Bas H.M. van der Velden, PhD,
  • Ramona K. Charaghvandi, PhD,
  • Celien P.H. Vreuls, PhD,
  • Paul J. van Diest, PhD,
  • A.M. Gijs van Leeuwen, MD,
  • Joost van Gorp, PhD,
  • Marielle E.P. Philippens, PhD,
  • Bram van Asselen, PhD,
  • Jan J.W. Lagendijk, PhD,
  • Helena M. Verkooijen, PhD,
  • H.J.G. Desirée van den Bongard, PhD,
  • Antonetta C. Houweling, PhD

Journal volume & issue
Vol. 7, no. 2
p. 100854

Abstract

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Purpose: We aimed to evaluate changes in dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) magnetic resonance imaging (MRI) scans acquired before and after single-dose ablative neoadjuvant partial breast irradiation (NA-PBI), and explore the relation between semiquantitative MRI parameters and radiologic and pathologic responses. Methods and Materials: We analyzed 3.0T DCE and DW-MRI of 36 patients with low-risk breast cancer who were treated with single-dose NA-PBI, followed by breast-conserving surgery 6 or 8 months later. MRI was acquired before NA-PBI and 1 week, 2, 4, and 6 months after NA-PBI. Breast radiologists assessed the radiologic response and breast pathologists scored the pathologic response after surgery. Patients were grouped as either pathologic responders or nonresponders (<10% vs ≥10% residual tumor cells). The semiquantitative MRI parameters evaluated were time to enhancement (TTE), 1-minute relative enhancement (RE1min), percentage of enhancing voxels (%EV), distribution of washout curve types, and apparent diffusion coefficient (ADC). Results: In general, the enhancement increased 1 week after NA-PBI (baseline vs 1 week median – TTE: 15s vs 10s; RE1min: 161% vs 197%; %EV: 47% vs 67%) and decreased from 2 months onward (6 months median – TTE: 25s; RE1min: 86%; %EV: 12%). Median ADC increased from 0.83 × 10−3 mm2/s at baseline to 1.28 × 10−3 mm2/s at 6 months. TTE, RE1min, and %EV showed the most potential to differentiate between radiologic responses, and TTE, RE1min, and ADC between pathologic responses. Conclusions: Semiquantitative analyses of DCE and DW-MRI showed changes in relative enhancement and ADC 1 week after NA-PBI, indicating acute inflammation, followed by changes indicating tumor regression from 2 to 6 months after radiation therapy. A relation between the MRI parameters and radiologic and pathologic responses could not be proven in this exploratory study.