Nature Communications (Aug 2019)
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
- Zachary J. Reitman,
- Brenton R. Paolella,
- Guillaume Bergthold,
- Kristine Pelton,
- Sarah Becker,
- Robert Jones,
- Claire E. Sinai,
- Hayley Malkin,
- Ying Huang,
- Leslie Grimmet,
- Zachary T. Herbert,
- Yu Sun,
- Jessica L. Weatherbee,
- John A. Alberta,
- John F. Daley,
- Orit Rozenblatt-Rosen,
- Alexandra L. Condurat,
- Kenin Qian,
- Prasidda Khadka,
- Rosalind A. Segal,
- Daphne Haas-Kogan,
- Mariella G. Filbin,
- Mario L. Suva,
- Aviv Regev,
- Charles D. Stiles,
- Mark W. Kieran,
- Liliana Goumnerova,
- Keith L. Ligon,
- Alex K. Shalek,
- Pratiti Bandopadhayay,
- Rameen Beroukhim
Affiliations
- Zachary J. Reitman
- Department of Cancer Biology, Dana Farber Cancer Institute
- Brenton R. Paolella
- Department of Cancer Biology, Dana Farber Cancer Institute
- Guillaume Bergthold
- Hoffmann-La Roche, Product Development, Innovative Pediatric Oncology Drug Discovery
- Kristine Pelton
- Department of Oncologic Pathology, Dana Farber Cancer Institute
- Sarah Becker
- Department of Oncologic Pathology, Dana Farber Cancer Institute
- Robert Jones
- Department of Oncologic Pathology, Dana Farber Cancer Institute
- Claire E. Sinai
- Department of Pediatric Oncology, Dana-Farber Boston Children’s Cancer and Blood Disorders Center
- Hayley Malkin
- Department of Cancer Biology, Dana Farber Cancer Institute
- Ying Huang
- Department of Oncologic Pathology, Dana Farber Cancer Institute
- Leslie Grimmet
- Molecular Biology Core Facilities, Dana-Farber Cancer Institute
- Zachary T. Herbert
- Molecular Biology Core Facilities, Dana-Farber Cancer Institute
- Yu Sun
- Department of Cancer Biology, Dana Farber Cancer Institute
- Jessica L. Weatherbee
- Department of Cancer Biology, Dana Farber Cancer Institute
- John A. Alberta
- Department of Cancer Biology, Dana Farber Cancer Institute
- John F. Daley
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Orit Rozenblatt-Rosen
- Broad Institute of MIT and Harvard
- Alexandra L. Condurat
- Broad Institute of MIT and Harvard
- Kenin Qian
- Department of Pediatric Oncology, Dana-Farber Boston Children’s Cancer and Blood Disorders Center
- Prasidda Khadka
- Department of Cancer Biology, Dana Farber Cancer Institute
- Rosalind A. Segal
- Department of Cancer Biology, Dana Farber Cancer Institute
- Daphne Haas-Kogan
- Department of Radiation Oncology, Dana-Farber Cancer Institute
- Mariella G. Filbin
- Broad Institute of MIT and Harvard
- Mario L. Suva
- Broad Institute of MIT and Harvard
- Aviv Regev
- Broad Institute of MIT and Harvard
- Charles D. Stiles
- Department of Cancer Biology, Dana Farber Cancer Institute
- Mark W. Kieran
- Department of Pediatric Oncology, Dana-Farber Boston Children’s Cancer and Blood Disorders Center
- Liliana Goumnerova
- Department of Neurosurgery, Boston Children’s Hospital
- Keith L. Ligon
- Broad Institute of MIT and Harvard
- Alex K. Shalek
- Broad Institute of MIT and Harvard
- Pratiti Bandopadhayay
- Broad Institute of MIT and Harvard
- Rameen Beroukhim
- Department of Cancer Biology, Dana Farber Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-019-11493-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.
