Auditory oddball responses in the human subthalamic nucleus and substantia nigra pars reticulata

Dallas Leavitt; Frhan I. Alanazi; Tameem M. Al-Ozzi; Melanie Cohn; Mojgan Hodaie; Suneil K. Kalia; Andres M. Lozano; Luka Milosevic; William D. Hutchison

Neurobiology of Disease (Jun 2024)

Auditory oddball responses in the human subthalamic nucleus and substantia nigra pars reticulata

Dallas Leavitt,
Frhan I. Alanazi,
Tameem M. Al-Ozzi,
Melanie Cohn,
Mojgan Hodaie,
Suneil K. Kalia,
Andres M. Lozano,
Luka Milosevic,
William D. Hutchison

Affiliations

Dallas Leavitt: Institute of Biomedical Engineering, University of Toronto, Canada; University of Toronto – Max Planck Centre for Neural Science and Technology, University of Toronto, Canada; Krembil Brain Institute, University Health Network, Toronto, Canada
Frhan I. Alanazi: Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Physiology, University of Toronto, Canada
Tameem M. Al-Ozzi: Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Physiology, University of Toronto, Canada
Melanie Cohn: Krembil Brain Institute, University Health Network, Toronto, Canada
Mojgan Hodaie: Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Surgery, University of Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital – University Health Network, Toronto, Canada
Suneil K. Kalia: Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Surgery, University of Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital – University Health Network, Toronto, Canada
Andres M. Lozano: Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Surgery, University of Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital – University Health Network, Toronto, Canada
Luka Milosevic: Institute of Biomedical Engineering, University of Toronto, Canada; University of Toronto – Max Planck Centre for Neural Science and Technology, University of Toronto, Canada; Krembil Brain Institute, University Health Network, Toronto, Canada; Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, Canada; KITE Research Institute, University Health Network, Toronto, Canada
William D. Hutchison: Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Physiology, University of Toronto, Canada; Department of Surgery, University of Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital – University Health Network, Toronto, Canada; Corresponding author at: Krembil Brain Institute, University Health Network, Toronto, Canada.

Journal volume & issue: Vol. 195
p. 106490

Abstract

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The auditory oddball is a mainstay in research on attention, novelty, and sensory prediction. How this task engages subcortical structures like the subthalamic nucleus and substantia nigra pars reticulata is unclear. We administered an auditory OB task while recording single unit activity (35 units) and local field potentials (57 recordings) from the subthalamic nucleus and substantia nigra pars reticulata of 30 patients with Parkinson's disease undergoing deep brain stimulation surgery. We found tone modulated and oddball modulated units in both regions. Population activity differentiated oddball from standard trials from 200 ms to 1000 ms after the tone in both regions. In the substantia nigra, beta band activity in the local field potential was decreased following oddball tones. The oddball related activity we observe may underlie attention, sensory prediction, or surprise-induced motor suppression.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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Abstract

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