Deoxynivalenol: An Overview on Occurrence, Chemistry, Biosynthesis, Health Effects and Its Detection, Management, and Control Strategies in Food and Feed

Madhu Kamle; Dipendra Kumar Mahato; Akansha Gupta; Shikha Pandhi; Bharti Sharma; Kajal Dhawan; Vasundhara; Sadhna Mishra; Manoj Kumar; Abhishek Dutt Tripathi; Prasad Rasane; Raman Selvakumar; Arvind Kumar; Shirani Gamlath; Pradeep Kumar

doi:10.3390/microbiolres13020023

Microbiology Research (Jun 2022)

Deoxynivalenol: An Overview on Occurrence, Chemistry, Biosynthesis, Health Effects and Its Detection, Management, and Control Strategies in Food and Feed

Madhu Kamle,
Dipendra Kumar Mahato,
Akansha Gupta,
Shikha Pandhi,
Bharti Sharma,
Kajal Dhawan,
Vasundhara,
Sadhna Mishra,
Manoj Kumar,
Abhishek Dutt Tripathi,
Prasad Rasane,
Raman Selvakumar,
Arvind Kumar,
Shirani Gamlath,
Pradeep Kumar

Affiliations

Madhu Kamle: Applied Microbiology Laboratory, Department of Forestry, North-Eastern Regional Institute of Science and Technology, Nirjuli 791109, India
Dipendra Kumar Mahato: CASS Food Research Centre, School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC 3125, Australia
Akansha Gupta: Department of Dairy Science and Food Technology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi 221005, India
Shikha Pandhi: Department of Dairy Science and Food Technology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi 221005, India
Bharti Sharma: Department of Dairy Science and Food Technology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi 221005, India
Kajal Dhawan: Department of Food Technology and Nutrition, School of Agriculture, Lovely Professional University, Phagwara 144411, India
Vasundhara: Department of Dairy Science and Food Technology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi 221005, India
Sadhna Mishra: Department of Dairy Science and Food Technology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi 221005, India
Manoj Kumar: Chemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai 400019, India
Abhishek Dutt Tripathi: Department of Dairy Science and Food Technology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi 221005, India
Prasad Rasane: Department of Food Technology and Nutrition, School of Agriculture, Lovely Professional University, Phagwara 144411, India
Raman Selvakumar: Centre for Protected Cultivation Technology, ICAR-Indian Agricultural Research Institute, Pusa Campus, New Delhi 110012, India
Arvind Kumar: Department of Dairy Science and Food Technology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi 221005, India
Shirani Gamlath: CASS Food Research Centre, School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC 3125, Australia
Pradeep Kumar: Applied Microbiology Laboratory, Department of Forestry, North-Eastern Regional Institute of Science and Technology, Nirjuli 791109, India

DOI: https://doi.org/10.3390/microbiolres13020023
Journal volume & issue: Vol. 13, no. 2
pp. 292 – 314

Abstract

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Mycotoxins are fungi-produced secondary metabolites that can contaminate many foods eaten by humans and animals. Deoxynivalenol (DON), which is formed by Fusarium, is one of the most common occurring predominantly in cereal grains and thus poses a significant health risk. When DON is ingested, it can cause both acute and chronic toxicity. Acute signs include abdominal pain, anorexia, diarrhea, increased salivation, vomiting, and malaise. The most common effects of chronic DON exposure include changes in dietary efficacy, weight loss, and anorexia. This review provides a succinct overview of various sources, biosynthetic mechanisms, and genes governing DON production, along with its consequences on human and animal health. It also covers the effect of environmental factors on its production with potential detection, management, and control strategies.

Published in Microbiology Research

ISSN: 2036-7481 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: https://www.mdpi.com/journal/microbiolres/

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