PENGARUH TERAPI SULIH HORMON ESTROGEN, PREPARAT KALSIUM DAN KOMBINASINYA PADA TULANG MANDIBULA (Studi eksperimental laboratorik pada tikus Wistar setelah ovariektomi)

Abstract

The purpose of this study was to evaluate the effects of ovariectomy, the influences of estrogen replacement therapy and/or suppelment CavitD3 on mandible's calcium contents of animal's models. Forty-five female rats were used in this research. Five rates were sacrificed for unoperated basal controls and the others were bilaterally ovariectomized. The ovariectomized animals were divided into 8 groups and two of these groups were only ovariectomized, the others were treated by estrogen replacement therapy. CavitD3 and combination of both per oral for 2 and 4 weeks and then were sacrificed. Mandible's calcium contents were analyzed by Ion Selective Electrode after demineralized with 10% phosphoric acid for 24 hours. Result : there were significant increased of mandible's calcium content at 2 weeks post-ovariectomy, but the results decreased at 4 weeks post-ovariectomy. Estrogen replacement therapy and treated with CavitD3 for 2 and 4 weeks or combination of both for 2 weeks increased the mandible's calcium contents of ovariectomized rats, but therapy combination with estrogen and CavitD3 for 4 weeks had a protective effect to mandible's calcium contents of ovariectomized rats.

Keywords

• ovariectomy
• estrogen replacement therapy
• suplemen calcium & vit D3
• mandible's calcium content
• osteoporosis
• Ion Selective Electrode method