Exploring the Anti-Cancer Effects of Fish Bone Fermented Using <i>Monascus purpureus</i>: Induction of Apoptosis and Autophagy in Human Colorectal Cancer Cells

Ya-Ting Chen; Shu-Jen Chen; Chun-Yi Hu; Cheng-Di Dong; Chiu-Wen Chen; Reeta Rani Singhania; Shu-Ling Hsieh

doi:10.3390/molecules28155679

Molecules (Jul 2023)

Exploring the Anti-Cancer Effects of Fish Bone Fermented Using <i>Monascus purpureus</i>: Induction of Apoptosis and Autophagy in Human Colorectal Cancer Cells

Ya-Ting Chen,
Shu-Jen Chen,
Chun-Yi Hu,
Cheng-Di Dong,
Chiu-Wen Chen,
Reeta Rani Singhania,
Shu-Ling Hsieh

Affiliations

Ya-Ting Chen: Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan
Shu-Jen Chen: Department of Chemical and Materials Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 80778, Taiwan
Chun-Yi Hu: Department of Food Science and Nutrition, Meiho University, Pingtung 912009, Taiwan
Cheng-Di Dong: Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan
Chiu-Wen Chen: Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan
Reeta Rani Singhania: Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan
Shu-Ling Hsieh: Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan

DOI: https://doi.org/10.3390/molecules28155679
Journal volume & issue: Vol. 28, no. 15
p. 5679

Abstract

Read online

Fish bone fermented using Monascus purpureus (FBF) has total phenols and functional amino acids that contribute to its anti-oxidant and anti-inflammatory properties. Colorectal cancer, one of the most prevalent cancers and the third largest cause of death worldwide, has become a serious threat to global health. This study investigates the anti-cancer effects of FBF (1, 2.5 or 5 mg/mL) on the cell growth and molecular mechanism of HCT-116 cells. The HCT-116 cell treatment with 2.5 or 5 mg/mL of FBF for 24 h significantly decreased cell viability (p p p p < 0.05). These results showed that FBF could inhibit HCT-116 cell growth by inducing S and G2/M phase arrest of the cell cycle, apoptosis and autophagy. Thus, FBF has the potential to treat colorectal cancer.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords