Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity

Benedikt Strunz; Julia Hengst; Katja Deterding; Michael P. Manns; Markus Cornberg; Hans-Gustaf Ljunggren; Heiner Wedemeyer; Niklas K. Björkström

doi:10.1038/s41467-018-04685-9

Nature Communications (Jun 2018)

Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity

Benedikt Strunz,
Julia Hengst,
Katja Deterding,
Michael P. Manns,
Markus Cornberg,
Hans-Gustaf Ljunggren,
Heiner Wedemeyer,
Niklas K. Björkström

Affiliations

Benedikt Strunz: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge
Julia Hengst: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge
Katja Deterding: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School
Michael P. Manns: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School
Markus Cornberg: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School
Hans-Gustaf Ljunggren: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge
Heiner Wedemeyer: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School
Niklas K. Björkström: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge

DOI: https://doi.org/10.1038/s41467-018-04685-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Natural killer (NK) cells are important immune cells for mediating antiviral immunity. Here the authors show that chronic hepatitis C virus infection in human can imprint lasting functional phenotypes in NK cells to increase their inter-individual but decrease intra-individual diversity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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