Response of the pranephral region tissues to the implementation of the xenopardial plate

Abstract

Background. A study was made of the response of the tissues of the perirenal region to the introduction of an implant made of xenomaterial. The purpose of the study is to identify patterns in the course of inflammatory and reparative processes in the perinephric region during the introduction of a xenopericardial implant. Materials and methods. An experimental study was carried out on rabbits of the Chinchilla breed, in which xenopericard fragments were introduced into the parrenal region. Results. The number of neutrophilic leukocytes (the main cells of the exudative phase of inflammation) is maximal in the early stages after surgery - on the 7th day 29.25 ± 1.28 cells in the field of view. The number of lymphoid and macrophage elements reaches a maximum three months after the operation - 19.3 ± 2.2 lymphocytes, then decreases. Own connective tissue grows throughout the entire period of the study, reaching a relative area of 69.9 ± 3.7% by the sixth month. Conclusions: xenopericardial plate causes an adequate response in body tissues, its introduction leads to the formation of dense connective tissue, which, however, allows maintaining kidney mobility.

Keywords

• xenopericardium
• implantation
• inflammation
• healing